Senior Clinical and Research Trial Physician - Neurosciences

• Support the timely delivery of clinical trials conducted within RDU 1 - Neurosciences to acceptable medical standards, in line with the requirements of sponsors, ICH GCP, and other appropriate guidelines and regulations.
• Provide medical assessment and cover for selected studies, working alongside the clinical research delivery team in RDU 1.
• Initiate definitive strategies to anticipate and expertly manage medical safety issues, including emergencies.
• Act as Sub-Investigator on designated research studies.
• Be responsible for specific study-related medical decisions as agreed with the Principal Investigator
• Assess participant eligibility against protocol-specific inclusion and exclusion criteria and maintaining up to date screening lists.
• Obtain informed consent in adherence to ICH GCP from study participants.
• Perform clinical assessments, medical histories and physical examinations and prescribing study medication.
• Perform clinical procedures as appropriate to the assigned study (including, but not limited to, clinical examinations or testing, insertion of intravenous lines, assessment of adverse events and management of medical emergencies)
• Evaluate and manage acute, sub-acute and chronic adverse drug reactions and manage acutetoxicological emergencies under the supervision of the consultants in charge.

• Participate in the design and conduct of clinical research projects.
• Present research findings at local, national and international meetings.
• Contribute to publications, abstracts and conference presentations.
• Support grant development and translational research activity where appropriate.
• Undertake audit and quality improvement projects.
• Contribute to teaching medical students, trainees and multidisciplinary research staff.
• Support training in clinical research and clinical procedures.
• Participate in departmental educational meetings and journal clubs.

Essential

• Medical degree (MBBS, MBChB or equivalent recognised qualification).
• Full GMC Registration with licence to practise
• Have completed ST1 - ST2 level post registration experience or equivalent.
• Current Good Clinical Practice (GCP) certification

Essential

• Experience managing acutely unwell patients
• Experience working within multidisciplinary teams
• Understanding of clinical trial methodology and research governance
• Experience of audit, quality improvement or service evaluation

Desirable

• Publications or presentations in peer-reviewed scientific settings
• Experience of advanced therapies, cellular therapies, gene therapies or regenerative medicine
• Previous involvement in clinical research studies including recruitment and eligibility assessment
• Participation in investigator meetings, monitoring visits or regulatory inspections

Essential

• Excellent communication and interpersonal skills
• Strong organisational and time-management skills
• Ability to obtain informed consent
• Understanding of patient safety and pharmacovigilance processes
• Ability to work independently whilst recognising limitations and seeking senior support appropriately
• Ability to interpret clinical investigations

Desirable

• Competency in neurological clinical procedures (such as lumbar punctures)
• Basic statistical analysis experience
• Knowledge of MHRA ATIMP regulations
• Understanding of translational and experimental medicine research
• Experience with electronic data capture systems and research databases